Genomic lesions associated with a different clinical outcome in diffuse large B-Cell lymphoma treated with R-CHOP-21

被引：38

作者：

Scandurra, Marta ^{[1
,2
]}

Mian, Michael ^{[1
,2
,3
]}

Greiner, Timothy C. ^{[4
]}

Rancoita, Paola M. V. ^{[1
,2
,5
]}

De Campos, Cassio P. ^{[1
,2
,5
]}

Chan, Wing C. ^{[4
]}

Vose, Julie M. ^{[4
]}

Chigrinova, Ekaterina ^{[1
,2
]}

Inghirami, Giorgio ^{[6
,7
]}

Chiappella, Annalisa ^{[8
]}

Baldini, Luca ^{[9
]}

Ponzoni, Maurilio ^{[10
,11
]}

Ferreri, Andres J. M. ^{[10
,11
]}

Franceschetti, Silvia ^{[12
,13
]}

Gaidano, Gianluca ^{[12
,13
]}

Montes-Moreno, Santiago ^{[14
]}

Piris, Miguel A. ^{[14
]}

Facchetti, Fabio ^{[15
,16
]}

Tucci, Alessandra ^{[15
,16
]}

Nomdedeu, Josep Fr ^{[17
,18
]}

Lazure, Thierry ^{[19
,20
]}

Lambotte, Olivier ^{[19
,20
]}

Uccella, Silvia ^{[21
,22
]}

Pinotti, Graziella ^{[21
,22
]}

Pruneri, Giancarlo ^{[23
,24
]}

Martinelli, Giovanni ^{[23
,24
]}

Young, Ken H. ^{[25
]}

Tibiletti, Maria Grazia ^{[21
,22
]}

Rinaldi, Andrea ^{[1
,2
]}

Zucca, Emanuele ^{[1
,2
]}

Kwee, Ivo ^{[1
,2
,5
]}

Bertoni, Francesco ^{[1
,2
]}

机构：

[1] Oncol Inst So Switzerland IOSI, Expt Oncol Lab, CH-6500 Bellinzona, Switzerland

[2] Oncol Inst So Switzerland IOSI, Lymphoma Unit, CH-6500 Bellinzona, Switzerland

[3] Azienda Osped S Maurizio, Div Haematol, Bolzano, Italy

[4] Univ Nebraska, Dept Pathol & Microbiol, Omaha, NE 68182 USA

[5] Ist Dalle Molle Studi Sullintelligenza Artificial, Manno, Switzerland

[6] Univ Turin, Dept Pathol, Turin, Italy

[7] Univ Turin, CeRMS, Turin, Italy

[8] AOU San Giovanni Battista, Haematol Sect 2, Dept Haematol & Oncol, Turin, Italy

[9] Univ Milan, Osped Maggiore Policlin MaRe, IRCCS, UO Ematol CTMO 1,Dipartimento Sci Med, Milan, Italy

[10] Ist Sci San Raffaele, Pathol Unit, Milan, Italy

[11] Unit Lymphoid Malignancies, Milan, Italy

[12] Amedeo Avogadro Univ Eastern Piedmont, Div Haematol, Dept Clin & Expt Med, Novara, Italy

[13] Amedeo Avogadro Univ Eastern Piedmont, BRMA, Novara, Italy

[14] Ctr Nacl Invest Oncol, Programa Patol Mol, Madrid, Spain

[15] Univ Brescia, Dept Pathol, Serv Anat Patol 1, Brescia, Italy

[16] Spedali Civil Brescia, Div Haematol, I-25125 Brescia, Italy

[17] Univ Autonoma Barcelona, Dept Haematol, Hosp Santa Creu i St Pau, E-08193 Barcelona, Spain

[18] Univ Autonoma Barcelona, Hematol Lab, Hosp Santa Creu i St Pau, E-08193 Barcelona, Spain

[19] Univ Hosp Bicetre, AP HP, Dept Internal Med, Le Kremlin Bicetre, France

[20] Univ Hosp Bicetre, AP HP, Dept Pathol, Le Kremlin Bicetre, France

[21] Univ Insubria, Osped Circolo, Anat Pathol Unit, Varese, Italy

[22] Univ Insubria, Osped Circolo, Dept Oncol, Varese, Italy

[23] European Inst Oncol, Div Pathol & Lab Med, Milan, Italy

[24] European Inst Oncol, Div Haematol, Milan, Italy

[25] Univ Wisconsin, Dept Pathol & Lab Med, Sch Med & Publ Hlth, Madison, WI USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2010年 / 151卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

prognosis; lymphoma; comparative genomic hybridization; microarray; hepatitis C virus; DECREASED EXPRESSION; INTEGRATIVE ANALYSIS; PREDICT; IDENTIFICATION; IMBALANCES; MUTATIONS; DELETIONS; PROFILES; SURVIVAL; SUBTYPES;

D O I：

10.1111/j.1365-2141.2010.08326.x

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

P>Despite recent therapeutic improvements, the clinical course of diffuse large B-cell lymphoma (DLBCL) still differs considerably among patients. We conducted this retrospective multi-centre study to evaluate the impact of genomic aberrations detected using a high-density genome wide-single nucleotide polymorphism-based array on clinical outcome in a population of DLBCL patients treated with R-CHOP-21 (rituximab, cyclophosphamide, doxorubicine, vincristine and prednisone repeated every 21 d). 166 DNA samples were analysed using the GeneChip Human Mapping 250K NspI. Genomic anomalies were analysed regarding their impact on the clinical course of 124 patients treated with R-CHOP-21. Unsupervised clustering was performed to identify genetically related subgroups of patients with different clinical outcomes. Twenty recurrent genetic lesions showed an impact on the clinical course. Loss of genomic material at 8p23.1 showed the strongest statistical significance and was associated with additional aberrations, such as 17p- and 15q-. Unsupervised clustering identified five DLBCL clusters with distinct genetic profiles, clinical characteristics and outcomes. Genetic features and clusters, associated with a different outcome in patients treated with R-CHOP, have been identified by arrayCGH.

引用

页码：221 / 231

页数：11

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