Genome wide DNA-profiling of HIV-related B-cell lymphomas

被引：55

作者：

Capello, Daniela ^{[2
,3
]}

Scandurra, Marta

Poretti, Giulia

Rancoita, Paola M. V. ^{[4
]}

Mian, Michael ^{[5
]}

Gloghini, Annunziata ^{[6
]}

Deambrogi, Clara ^{[2
,3
]}

Martini, Maurizio ^{[7
]}

Rossi, Davide ^{[2
,3
]}

Greiner, Timothy C. ^{[8
]}

Chan, Wing C. ^{[8
]}

Ponzoni, Maurilio ^{[9
,10
]}

Moreno, Santiago M. ^{[11
]}

Piris, Miguel A. ^{[11
]}

Canzonieri, Vincenzo ^{[12
]}

Spina, Michele ^{[12
]}

Tirelli, Umberto ^{[12
]}

Inghirami, Giorgio ^{[13
]}

Rinaldi, Andrea

Zucca, Emanuele

Favera, Riccardo D. ^{[14
,15
]}

Cavalli, Franco

Larocca, Luigi Maria ^{[7
]}

Kwee, Ivo ^{[4
]}

Carbone, Antonino ^{[6
]}

Gaidano, Gianluca ^{[2
,3
]}

Bertoni, Francesco ^{[1
]}

机构：

[1] Oncol Inst So Switzerland IOSI, Expt Oncol Lab, CH-6500 Bellinzona, Switzerland

[2] Amedeo Avogadro Univ Eastern Piedmont, Div Haematol, Dept Clin & Expt Med, Novara, Italy

[3] Amedeo Avogadro Univ Eastern Piedmont, BRMA, Novara, Italy

[4] Ist Dalle Molle Studi Intelligenza Artificial IDS, Manno, Switzerland

[5] Azienda Osped S Maurizio, Div Ematol, Bolzano, Italy

[6] INT, Div Pathol, Milan, Italy

[7] Univ Cattolica Sacro Cuore, Dept Pathol, I-00168 Rome, Italy

[8] Univ Nebraska, Dept Pathol & Microbiol, Omaha, NE 68182 USA

[9] San Raffaele H Sci Inst Milan, Pathol Unit, Milan, Italy

[10] San Raffaele H Sci Inst Milan, Unit Lymphoid Malignancies, Milan, Italy

[11] Ctr Nacl Invest Oncol, Programa Patol Mol, Madrid, Spain

[12] CRO INT, Div Oncol & Pathol, Aviano, Italy

[13] Univ Turin, Dept Biomed Sci & Human Oncol, Ctr Expt Med & Res CeRMS, I-10124 Turin, Italy

[14] Columbia Univ, Inst Canc Genet, New York, NY USA

[15] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2010年 / 148卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

acquired immunodeficiency syndrome; Fragile Histidine Triad; WW domain-containing Oxidoreductase; diffuse large B-cell lymphoma; Affymetrix; PRIMARY EFFUSION LYMPHOMA; GENE-EXPRESSION PROFILE; AIDS-RELATED LYMPHOMAS; COMMON FRAGILE SITES; EPSTEIN-BARR-VIRUS; LYMPHOPROLIFERATIVE DISORDERS; BURKITTS-LYMPHOMA; CANCER; WWOX; REVEALS;

D O I：

10.1111/j.1365-2141.2009.07943.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>Non-Hodgkin lymphomas (NHL) represent a frequent complication of human immunodeficiency virus (HIV) infection. To elucidate HIV-NHL pathogenesis, we performed a genome-wide DNA profiling based on a single nucleotide polymorphism-based microarray comparative genomic hybridization in 57 HIV-lymphomas and, for comparison, in 105 immunocompetent diffuse large B-cell lymphomas (IC-DLBCL). Genomic complexity varied across HIV-NHL subtypes. HIV-Burkitt lymphoma showed a significantly lower number of lesions than HIV-DLBCL (P = 0 center dot 032), whereas the median number of copy number changes was significantly higher in Epstein-Barr virus negative (EBV-) HIV-DLBCL (42 center dot 5, range 8-153) compared to EBV+ cases (22; range 3-41; P = 0 center dot 029). Compared to IC-DLBCL, HIV-DLBCL displayed a distinct genomic profile with no gains of 18q and specific genetic lesions. Fragile sites-associated genes, including FHIT (FRA3B), WWOX (FRA16D), DCC (FRA18B) and PARK2 (FRA6E) were frequently inactivated in HIV-NHL by interstitial deletions, and a significantly higher prevalence of FHIT alterations was observed in HIV-DLBCL compared to IC-DLBCL. The same genes involved by fragile site deletions were also frequently affected by aberrant methylation of regulative regions.

引用

页码：245 / 255

页数：11

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