Netrin-1 and its receptors in tumorigenesis

被引：214

作者：

Arakawa, H ^{[1
]}

机构：

[1] Natl Canc Ctr, Canc Med & Biophys Div, Chuo Ku, Tokyo 1040045, Japan

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 12期

关键词：

D O I：

10.1038/nrc1504

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Netrin-1 and its receptors DCC (deleted in colorectal cancer) and the UNC5 orthologues (human UNC5A-D and rodent UNC5H1-4) define a new mechanism for both the positive (induction) and negative (suppression) regulation of apoptosis. Accumulating evidence implies that for human cancers, this positive signalling pathway is frequently inactivated. Surprisingly, binding of netrin-1 to its receptors inhibits tumour suppressor p53-dependent apoptosis, and p53 is directly involved in transcriptional regulation of netrin-1 and its receptors. So, the netrin-1 receptor pathways probably play an important part in tumorigenesis.

引用

页码：978 / 987

页数：10

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