Novel inhibitors of fungal protein synthesis produced by a strain of Graphium putredinis -: Isolation, characterisation and biological properties

被引：20

作者：

Kennedy, TC ^{[1
]}

Webb, G ^{[1
]}

Cannell, RJP ^{[1
]}

Kinsman, OS ^{[1
]}

Middleton, RF ^{[1
]}

Sidebottom, PJ ^{[1
]}

Taylor, NL ^{[1
]}

Dawson, MJ ^{[1
]}

Buss, AD ^{[1
]}

机构：

[1] Glaxo Wellcome Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 11期

关键词：

D O I：

10.7164/antibiotics.51.1012

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The isolation and structure determination of 6 analogues of the fungal. protein synthesis inhibitor GR135402, from Graphium putredinis, is described. The relative potencies of the compounds as protein synthesis inhibitors and as in vitro antifungal agents provide interesting insights into the structure-activity relationships in this series.

引用

页码：1012 / 1018

页数：7

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