Pharmaceutical cocrystals: An overview

被引：513

作者：

Qiao, Ning ^{[1
]}

Li, Mingzhong ^{[1
]}

Schlindwein, Walkiria ^{[1
]}

Malek, Nazneen ^{[1
]}

Davies, Angela ^{[1
]}

Trappitt, Gary ^{[1
]}

机构：

[1] De Montfort Univ, Sch Pharm, Leicester LE1 9BH, Leics, England

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2011年 / 419卷 / 1-2期

关键词：

Pharmaceutical cocrystal; Crystal engineering; Supramolecular synthon; Solution cocrystallisation; Grinding cocrystallisation; Cocrystal characterisation; HYDROGEN-BOND PATTERNS; CO-CRYSTALS; PHYSICOCHEMICAL PROPERTIES; SUPRAMOLECULAR SYNTHONS; PHYSICAL STABILITY; DISSOLUTION; CARBAMAZEPINE; BIOAVAILABILITY; INDOMETHACIN; ACIDS;

D O I：

10.1016/j.ijpharm.2011.07.037

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pharmaceutical cocrystals are emerging as a new class of solid drugs with improved physicochemical properties, which has attracted increased interests from both industrial and academic researchers. In this paper a brief and systematic overview of pharmaceutical cocrystals is provided, with particular focus on cocrystal design strategies, formation methods, physicochemical property studies, characterisation techniques, and recent theoretical developments in cocrystal screening and mechanisms of cocrystal formations. Examples of pharmaceutical cocrystals are also summarised in this paper. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1 / 11

页数：11

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