Gastric cytoprotective activity of ilicic aldehyde:: Structure-activity relationships

被引：25

作者：

Donadel, OJ ^{[1
]}

Guerreiro, E

María, AO

Wendel, G

Enriz, RD

Giordano, OS

Tonn, CE

机构：

[1] Univ Nacl San Luis, Fac Quim Bioquim & Farm, CONICET, INTEQUI, RA-5700 San Luis, Argentina

[2] Univ Nacl San Luis, Fac Quim Bioquim & Farm, Dept Farm, RA-5700 San Luis, Argentina

[3] Univ Nacl San Luis, Fac Quim Bioquim & Farm, Dept Quim, RA-5700 San Luis, Argentina

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 15期

关键词：

gastric cytoprotection; sesquiterpenes; ilicic aldehyde; eudesmane; eremophilane;

D O I：

10.1016/j.bmcl.2005.05.053

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A series of sesquiterpene compounds possessing both eudesmane and eremophilane skeletons were tested as gastric cyto-protective agents on male Wistar rats. The presence of an alpha,beta-unsaturated aldehyde on the C-7 side chain together with a hydroxyl group at C-4 is the requirement for the observed antiulcerogenic activity. In an attempt to establish new molecular structural requirements for this gastric cytoprotective activity, a structure-activity study was performed. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3547 / 3550

页数：4

共 20 条

[1]

New sesquiterpenoids from the Jordanian medicinal plant Inula viscosa [J].

Abu Zarga, MH ;

Hamed, EM ;

Sabri, SS ;

Voelter, W ;

Zeller, KP .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (06) :798-800

[2]

MECHANISMS OF PROTECTION BY OMEPRAZOLE AGAINST EXPERIMENTAL GASTRIC-MUCOSAL DAMAGE IN RATS [J].

BLANDIZZI, C ;

GHERARDI, G ;

MARVEGGIO, C ;

NATALE, G ;

CARIGNANI, D ;

DELTACCA, M .

DIGESTION, 1995, 56 (03) :220-229

[3]

NATURALLY-OCCURRING TERPENE DERIVATIVES .464. HIRSUTINOLIDES FROM SOUTH-AFRICAN VERNONIA SPECIES [J].

BOHLMANN, F ;

ATES, N ;

JAKUPOVIC, J .

PHYTOCHEMISTRY, 1983, 22 (05) :1159-1162

[4]

Denny R. W., 1973, ORG REACTIONS, V20, P133, DOI DOI 10.1002/0471264180.0R020.02

[5]

Donadel OJ, 1998, AN ASOC QUIM ARGENT, V86, P90

[6]

Donadel OJ, 2001, RAPID COMMUN MASS SP, V15, P164, DOI 10.1002/1097-0231(20010130)15:2<164::AID-RCM199>3.3.CO

[7]

2-5

[8]

FIESER LF, 1967, REAGENTS ORGANIC SYN, V1, P142

[9]

STRUCTURE ACTIVITY RELATIONSHIP IN THE GASTRIC CYTOPROTECTIVE EFFECT OF SEVERAL SESQUITERPENE LACTONES [J].

GIORDANO, OS ;

PESTCHANKER, MJ ;

GUERREIRO, E ;

SAAD, JR ;

ENRIZ, RD ;

RODRIGUEZ, AM ;

JAUREGUI, EA ;

GUZMAN, J ;

MARIA, AOM ;

WENDEL, GH .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (13) :2452-2458

[10]

GIORDANO OS, 1979, REV LATINOAM QUIM, V6, P131

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