Current progress in pharmacogenetics

被引：12

作者：

Blakey, John D. ^{[1
]}

Hall, Ian P. ^{[2
]}

机构：

[1] Resp Biomed Res Unit, Nottingham NG5 1PB, England

[2] Queens Med Ctr, Div Therapeut & Mol Med, Nottingham NG7 2UH, England

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2011年 / 71卷 / 06期

基金：

英国惠康基金;

关键词：

adverse drug effects; genome-wide association; pharmacogenetics; GENOME-WIDE ASSOCIATION; POLYMORPHISMS; GENOTYPE; DETERMINANT; EDUCATION; THERAPY; ASTHMA; IMPACT;

D O I：

10.1111/j.1365-2125.2011.03912.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The study of genetic variation has the potential to aid understanding of the mechanisms underlying the observed inter-individual variation in drug response and by which idiosyncratic adverse effects occur. In this review, we outline current progress in pharmacogenetics using examples to highlight both mechanisms of influence of polymorphisms and research strategies for their detection. In the final sections we discuss contemporary challenges for both researchers and clinicians.

引用

页码：824 / 831

页数：8

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