Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation

被引：113

作者：

Ghizzoni, Massimo ^{[1
]}

Haisma, Hidde J. ^{[1
]}

Maarsingh, Harm ^{[2
]}

Dekker, Frank J. ^{[1
]}

机构：

[1] Univ Groningen, Dept Pharmaceut Gene Modulat, Groningen Res Inst Pharm, NL-9713 AV Groningen, Netherlands

[2] Univ Groningen, Dept Mol Pharmacol, Groningen Res Inst Pharm, NL-9713 AV Groningen, Netherlands

来源：

DRUG DISCOVERY TODAY | 2011年 / 16卷 / 11-12期

关键词：

DEPENDENT GENE-EXPRESSION; CREB-BINDING PROTEIN; SMOOTH-MUSCLE-CELLS; H4; ACETYLATION; ANACARDIC ACID; IN-VIVO; TRANSCRIPTIONAL ACTIVATION; CHROMATIN TRANSCRIPTION; DEACETYLASE ACTIVITY; LUNG INFLAMMATION;

D O I：

10.1016/j.drudis.2011.03.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Post-translational modifications of proteins, such as acetylation, are important regulatory events in eukaryotic cells. Reversible acetylations of histones and non-histone proteins regulate gene expression and protein activity. Acetylation levels of proteins are regulated by a dynamic equilibrium between acetylation by (histone) acetyltransferases and deacetylation by (histone) deacetylases. Alterations in this equilibrium can result in pathological states. Inflammation is a physiological response that, under certain conditions, turns into a disease. This review focuses on the crucial regulatory roles of protein acetylation in NF-kappa B-mediated inflammation and the potential applications of small-molecule inhibitors of acetylation for the treatment of inflammatory diseases.

引用

收藏

页码：504 / 511

页数：8

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