Evolution of bioinorganic motifs in P450-containing systems

被引：23

作者：

Degtyarenko, KN ^{[1
]}

Kulikova, TA ^{[1
]}

机构：

[1] European Bioinformat Inst, EMBL Outstn, Cambridge CB10 1SD, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2001年 / 29卷

关键词：

cytochrome b(5); electron transfer; ferredoxin; flavoprotein; genome;

D O I：

10.1042/BST0290139

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The choice of bioinorganic motifs by Nature results in a spectacular variety of active-site structures even within the same protein family. Here, we use the concept of the bioinorganic motif to discuss the function and evolution of P450-containing and other related systems. Apart from P450, these systems include a FAD flavoprotein or domain, a FMN domain, ferredoxins and cytochrome b(5). Analysis of available complete genomes can shed light on what an ancestral P450-containing system could be.

引用

页码：139 / 147

页数：9

共 50 条

[1] ROLES OF PROXIMAL LIGAND IN HEME-PROTEINS - REPLACEMENT OF PROXIMAL HISTIDINE OF HUMAN MYOGLOBIN WITH CYSTEINE AND TYROSINE BY SITE-DIRECTED MUTAGENESIS AS MODELS FOR P-450, CHLOROPEROXIDASE, AND CATALASE [J].

ADACHI, S ;

NAGANO, S ;

ISHIMORI, K ;

WATANABE, Y ;

MORISHIMA, I ;

EGAWA, T ;

KITAGAWA, T ;

MAKINO, R .

BIOCHEMISTRY, 1993, 32 (01) :241-252

[2] The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000 [J].

Bairoch, A ;

Apweiler, R .

NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :45-48

[3] The Protein Data Bank [J].

Berman, HM ;

Westbrook, J ;

Feng, Z ;

Gilliland, G ;

Bhat, TN ;

Weissig, H ;

Shindyalov, IN ;

Bourne, PE .

NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :235-242

[4] EVIDENCE FOR CONFORMATIONAL DYNAMICS AND MOLECULAR AGGREGATION IN CYTOCHROME-P450-102 (BM-3) [J].

BLACK, SD ;

MARTIN, ST .

BIOCHEMISTRY, 1994, 33 (40) :12056-12062

[5]

CHRISTNER JA, 1981, J BIOL CHEM, V256, P2098

[6] Non-haem iron-containing oxygenases involved in the microbial biodegradation of aromatic hydrocarbons [J].

Coulter, ED ;

Ballou, DP .

ESSAYS IN BIOCHEMISTRY, VOL 34, 1999: METALLOPROTEINS, 1999, 34 :31-49

[7] The relationship between structure and function for the sulfite reductases [J].

Crane, BR ;

Getzoff, ED .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1996, 6 (06) :744-756

[8]

de Montellano PRO, 2000, CURR OPIN CHEM BIOL, V4, P221

[9] Bioinorganic motifs: towards functional classification of metalloproteins [J].

Degtyarenko, K .

BIOINFORMATICS, 2000, 16 (10) :851-864

[10] STRUCTURAL DOMAINS OF P450-CONTAINING MONOOXYGENASE SYSTEMS [J].

DEGTYARENKO, KN .

PROTEIN ENGINEERING, 1995, 8 (08) :737-747

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