Stellettins L and M, cytotoxic isomalabaricane-type triterpenes, and sterols from the marine sponge Stelletta tenuis

被引：23

作者：

Lin, Hou-wen

Wang, Zeng-lei

Wu, Jiu-hong

Shi, Ning

Zhang, Hong-jun

Chen, Wan-sheng

Morris-Natschke, Susan L.

Lin, An-Shen

机构：

[1] Second Mil Med Univ, Changzhen Hosp, Dept Pharm, Lab Marine Drugs, Shanghai 200003, Peoples R China

[2] Dept Pharm, Beijing 100101, Peoples R China

[3] Univ N Carolina, Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 07期

关键词：

D O I：

10.1021/np070069l

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new isomalabaricane-type triterpenes, stellettins L (1) and M (2), and three new sterols (3-5) were isolated from the marine sponge Stelletta tenuis collected in the South China Sea. Chemical structures were established from spectroscopic data and comparison with known compounds. In addition, spectroscopic data reported for the known sterol 24-methylene-27-methylcholest-5-en-3 beta-ol-7-one (6) were revised. Compounds 1 and 2 exhibited significant cytotoxic activity against stomach cancer ( AGS) in vitro.

引用

页码：1114 / 1117

页数：4

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