Clean and fast oxidative transformation of thiols to disulfides under solvent-free conditions

被引：69

作者：

Lenardao, Eder J. ^{[1
]}

Lara, Renata G. ^{[1
]}

Silva, Marcio S. ^{[1
]}

Jacob, Raquel G. ^{[1
]}

Perin, Gelson ^{[1
]}

机构：

[1] Univ Fed Pelotas, Inst Quim Geociencias, LASOL, UFPel, BR-96010900 Pelotas, RS, Brazil

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 43期

关键词：

microwave irradiation; solid-supported catalysis; solvent-free reaction; disulfides;

D O I：

10.1016/j.tetlet.2007.08.094

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We present here a fast, solvent-free synthesis of symmetrical disulfides using solid supported catalyst (Al-2,O-3/KF). The reaction was performed at room temperature, by gentle heating or under MW irradiation. This efficient and improved method is general for liquid thiols, affording the disulfides in good to excellent yields. The catalytic system can be re-used two times without previous treatment and with comparable activity. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：7668 / 7670

页数：3

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