Glycosaminoglycan mimetic biomaterials. 2. Alkene- and acrylate-derivatized glycopolymers via cyanoxyl-mediated free-radical polymerization

被引：59

作者：

Grande, D

Baskaran, S

Chaikof, EL ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Surg, Lab Biomol Mat Res, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Dept Bioengn, Atlanta, GA 30322 USA

[3] Georgia Inst Technol, Sch Chem Engn, Atlanta, GA 30320 USA

来源：

MACROMOLECULES | 2001年 / 34卷 / 06期

关键词：

D O I：

10.1021/ma001680t

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Cyanoxyl ((OC)-O-. dropN)-mediated free-radical polymerization provides an effective and versatile method for engineering a diverse array of water-soluble glycopolymers with high saccharide contents and low polydispersity indexes (1.1 < M-w/M-n < 1.6). Cyanoxyl persistent radicals can be used as chain-growth moderators of the statistical copolymerization of acrylamide with either nonsulfated or sulfated N-acetyl-D-glucosamine-carrying alkene- and acrylate-derivatized unprotected glycomonomers. Moreover, monosaccharide-containing homopolymers can be prepared with some degree of control by polymerization of the acrylic glycomonomers.

引用

页码：1640 / 1646

页数：7

共 36 条

[1] Docking of glycosaminoglycans to heparin-binding proteins: Validation for aFGF, bFGF, and antithrombin and application to IL-8 [J].