Resolution of 1-(4-amino-3-chloro-5-cyanophenyl)-2-bromo-1-ethanol by lipase mediated enantioselective alcoholysis, hydrolysis and acylation

被引：13

作者：

Conde, S

Fierros, M

Rodríguez-Franco, MI

Puig, C

机构：

[1] CSIC, Inst Quim Med, E-28006 Madrid, Spain

[2] Ctr Invest, Labs ALMIRALL PRODESFARMA, Barcelona 08024, Spain

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 13期

关键词：

D O I：

10.1016/S0957-4166(98)00252-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Resolution of 1-(4-amino-3-chloro-5-cyanophenyl)-2-bromo-1-ethanol has been achieved by ethanol enantio-selective lipase-catalysed alcoholysis, hydrolysis and acylation. Although a good enantioselectivity was observed in the three reactions, the best results were obtained by hydrolysis. This alpha-bromohydrin is an intermediate in the synthesis of a new adrenergic agent. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2229 / 2232

页数：4

共 12 条

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