Efficacy of sulforaphane in eradicating Helicobacter pylori in human gastric xenografts implanted in nude mice

被引：76

作者：

Haristoy, X

Angioi-Duprez, K

Duprez, A

Lozniewski, A

机构：

[1] CNRS, UMR 7565, Lab Bacteriol Virol, Vandoeuvre Les Nancy, France

[2] INSERM, Lab Microchirurg Expt, F-54511 Vandoeuvre Les Nancy, France

[3] INSERM, Anat Pathol Lab, F-54511 Vandoeuvre Les Nancy, France

[4] Univ Henri Poincare, Fac Med, Vandoeuvre Les Nancy, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 12期

关键词：

D O I：

10.1128/AAC.47.12.3982-3984.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Sulforaphane, an isothiocyanate abundant in the form of its glucosinolate precursor in broccoli sprouts, has shown in vitro activity against Helicobacter pylori. We evaluated the effect of sulforaphane in vivo against this bacterium by using human gastric xenografts in nude mice. H. pylori was completely eradicated in 8 of the 11 sulforaphane-treated grafts. This result suggests that sulforaphane might be beneficial in the treatment of H. pylori-infected individuals.

引用

页码：3982 / 3984

页数：3

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