Fluorescent-magnetic hybrid nanostructures: Preparation, properties, and applications in biology

被引：90

作者：

Quarta, Alessandra ^{[1
,2
]}

Di Corato, Riccardo ^{[1
,2
]}

Manna, Liberato ^{[1
,2
]}

Ragusa, Andrea ^{[1
,2
]}

Pellegrino, Teresa ^{[1
,2
]}

机构：

[1] INFM, CNR, NNL Nanotechnol Lab, Unita Ric IIT, I-73100 Lecce, Italy

[2] Scuola Super ISUFI, I-73100 Lecce, Italy

来源：

IEEE TRANSACTIONS ON NANOBIOSCIENCE | 2007年 / 6卷 / 04期

关键词：

fluorescent materials; hybrid materials; magnetic nanoparticles; nanocomposites;

D O I：

10.1109/TNB.2007.908989

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Research on nanocomposite materials aims at developing nanoscale composites with innovative optical, chemical, and magnetic properties, all combined in one single nanostructure. In this scenario, nanostructures which show simultaneously fluorescent and magnetic features are of particular interest for pharmaceutical and biomedical applications. In this review, we will focus our attention on magnetic-fluorescent nanocomposite based on colloidal iron oxide nanocrystals combined with different classes of fluorophores which can be either organic dyes, such as fluoresceins, cyanines, porphyrins, or colloidal quantum dots. We will give an overview of the preparation methods of the magnetic-fluorescent nanocomposites that are now available and we will outline the most significant in vitro studies of such nanocomposites on living cells. Some examples of their applications in biology and medicine will also be discussed.

引用

页码：298 / 308

页数：11

共 80 条

[21] Poly(N-isopropylacrylamide)-coated luminescent/magnetic silica microspheres:: Preparation, characterization, and biomedical applications [J].

Guo, Jia ;

Yang, Wuli ;

Wang, Changchun ;

He, Jia ;

Chen, Jiyao .

CHEMISTRY OF MATERIALS, 2006, 18 (23) :5554-5562

[22] Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications [J].

Gupta, Ajay Kumar ;

Naregalkar, Rohan R. ;

Vaidya, Vikas Deep ;

Gupta, Mona .

NANOMEDICINE, 2007, 2 (01) :23-39

[23] Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications [J].

Gupta, AK ;

Gupta, M .

BIOMATERIALS, 2005, 26 (18) :3995-4021

[24]

Holmes KL, 2001, METHOD CELL BIOL, V63, P185

[25] Synthesis and biomedical applications of functionalized fluorescent and magnetic dual reporter nanoparticles as obtained in the miniemulsion process [J].

Holzapfel, Verena ;

Lorenz, Myriam ;

Weiss, Clemens Kilian ;

Schrezenmeier, Hubert ;

Landfester, Katharina ;

Mailaender, Volker .

JOURNAL OF PHYSICS-CONDENSED MATTER, 2006, 18 (38) :S2581-S2594

[26] Fabrication of magnetic luminescent nanocomposites by a layer-by-layer self-assembly approach [J].

Hong, X ;

Li, J ;

Wang, MJ ;

Xu, JJ ;

Guo, W ;

Li, JH ;

Bai, YB ;

Li, TJ .

CHEMISTRY OF MATERIALS, 2004, 16 (21) :4022-4027

[27] Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification [J].

Hoshino, A ;

Fujioka, K ;

Oku, T ;

Suga, M ;

Sasaki, YF ;

Ohta, T ;

Yasuhara, M ;

Suzuki, K ;

Yamamoto, K .

NANO LETTERS, 2004, 4 (11) :2163-2169

[28] Synthesis, properties, and applications of iron nanoparticles [J].

Huber, DL .

SMALL, 2005, 1 (05) :482-501

[29] Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes [J].

Josephson, L ;

Kircher, MF ;

Mahmood, U ;

Tang, Y ;

Weissleder, R .

BIOCONJUGATE CHEMISTRY, 2002, 13 (03) :554-560

[30] High-efficiency intracellular magnetic labeling with novel superparamagnetic-tat peptide conjugates [J].

Josephson, L ;

Tung, CH ;

Moore, A ;

Weissleder, R .

BIOCONJUGATE CHEMISTRY, 1999, 10 (02) :186-191

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