Synthesis and reactivity of lithium tri(quinolinyl)magnesates

被引：60

作者：

Dumouchel, S ^{[1
]}

Mongin, F ^{[1
]}

Trécourt, F ^{[1
]}

Quéguiner, G ^{[1
]}

机构：

[1] IRCOF, UMR 6014, Lab Chim Organ Fine & Heterocycl, F-76131 Mont St Aignan, France

来源：

TETRAHEDRON | 2003年 / 59卷 / 43期

关键词：

quinolines; ate complexes; in situ IR; cross-coupling;

D O I：

10.1016/j.tet.2003.06.001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-, 3- and 4-Bromoquinolines, were converted to the corresponding lithium tri(quinolinyl)magnesates at -10degreesC when exposed to Bu3MgLi in THF. The resulting organomagnesium derivatives were quenched with various electrophiles or involved in metal-catalyzed coupling reactions with heteroaryl halides to afford functionalized quinolines. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：8629 / 8640

页数：12