Caspases: key mediators of apoptosis

被引：386

作者：

Thornberry, NA ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Sharp & Dohme Res Labs, Rahway, NJ 07065 USA

来源：

CHEMISTRY & BIOLOGY | 1998年 / 5卷 / 05期

关键词：

D O I：

10.1016/S1074-5521(98)90615-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have established that members of the caspase protease family are essential components of a conserved cell death program. Insights into their biological roles, structure and mechanism are enabling investigators to begin to explore the therapeutic potential of caspase inhibition.

引用

页码：R97 / R103

页数：7