Chemoenzymatic synthesis of structured triacylglycerols by highly regioselective acylation

被引:86
作者
Halldorsson, A [1 ]
Magnusson, CD [1 ]
Haraldsson, GG [1 ]
机构
[1] Univ Iceland, Inst Sci, Dept Chem, IS-107 Reykjavik, Iceland
关键词
Candida antarctica lipase; EPA; DHA; lipase; regioselectivity; structured triacylglycerols; vinyl esters;
D O I
10.1016/j.tet.2003.09.059
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A highly efficient two-step chemoenzymatic synthesis of structured triacylglycerols comprising a pure n-3 polyunsaturated fatty acid at the mid-position and a pure saturated fatty acid located at the end-positions is described. In the first step an immobilized Candida antarctica lipase was observed to display an excellent regioselectivity toward the end-positions of glycerol at 0-4degreesC using vinyl esters as acylating agents. The n-3 fatty acids were introduced into the remaining mid-position highly efficient and in excellent yields using EDCI coupling agent. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:9101 / 9109
页数:9
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