Function of zebrafish β-catenin and TCF-3 in dorsoventral patterning

被引：60

作者：

Pelegri, F ^{[1
]}

Maischein, HM ^{[1
]}

机构：

[1] Max Planck Inst Entwicklungsbiol, D-72076 Tubingen, Germany

来源：

MECHANISMS OF DEVELOPMENT | 1998年 / 77卷 / 01期

关键词：

beta-catenin; Tcf-3; Wnt pathway; Nieuwkoop center; Spemann organizer; axis induction; dorsoventral patterning; zebrafish;

D O I：

10.1016/S0925-4773(98)00132-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report the molecular cloning and expression of the zebrafish tcf-3 homologue and study its function and that of zebrafish beta cat in dorsoventral patterning. Overexpression of mutant zTcf-3 products and Cadherin leads to a reduction in the expression of the dorsal-specific genes goosecoid and chordino at the blastula stages, indicating a conserved role for beta cat and Tcf-3 in zebrafish dorsal axis induction. Later during gastrulation, overexpression of these same products leads to the ectopic expression of dorsal-specific genes in the marginal zone and the induction of ectopic axes, suggesting an additional role for beta cat and Tcf-3 at these later stages in the repression of dorsal fates. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：63 / 74

页数：12

共 63 条

[51]

Sakai M, 1996, DEVELOPMENT, V122, P2207

[52] beta-Catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos [J].

Schneider, S ;

Steinbeisser, H ;

Warga, RM ;

Hausen, P .

MECHANISMS OF DEVELOPMENT, 1996, 57 (02) :191-198

[53]

SCHULTEMERKER S, 1994, DEVELOPMENT, V120, P843

[54] The zebrafish organizer requires chordino [J].

SchulteMerker, S ;

Lee, KJ ;

McMahon, AP ;

Hammerschmidt, M .

NATURE, 1997, 387 (6636) :862-863

[55]

Shih J, 1996, DEVELOPMENT, V122, P1313

[56] INDUCING FACTORS IN XENOPUS EARLY EMBRYOS [J].

SLACK, JMW .

CURRENT BIOLOGY, 1994, 4 (02) :116-126

[57] INJECTED XWNT-8 RNA ACTS EARLY IN XENOPUS EMBRYOS TO PROMOTE FORMATION OF A VEGETAL DORSALIZING CENTER [J].

SMITH, WC ;

HARLAND, RM .

CELL, 1991, 67 (04) :753-765

[58] Analysis of dishevelled signalling pathways during Xenopus development [J].

Sokol, SY .

CURRENT BIOLOGY, 1996, 6 (11) :1456-1467

[59]

STACHEL SE, 1993, DEVELOPMENT, V117, P1261

[60] Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8 [J].

Wang, SW ;

Krinks, M ;

Lin, KM ;

Luyten, FP ;

Moos, M .

CELL, 1997, 88 (06) :757-766

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