Estimation of influence of gastric emptying on shape of glucose concentration-time profile measured in oral glucose tolerance test

Aims: To develop a model for simulations of processes in the oral glucose tolerance test (OGTT), using tools of the theory of dynamic systems. Methods: Frequent sampling OGTT was performed in 13 healthy subjects (6 males and 7 females). Subsequently, employing glucose and insulin concentration-time profiles of the subjects, the model was developed. Results: In all subjects the model was able to simulate influences of the insulin plasma concentration and gastric emptying rate on glucose concentration and to determine time profiles of glucose fractions retained in stomach. Conclusions: The approach presented represents an opportunity for building models for data analyses in OGTT. (c) 2007 Elsevier Ireland Ltd. All rights reserved.