A system-approach method for the adjustment of time-varying continuous drug infusion in individual patients:: A simulation study

被引：6

作者：

Durisová, M

Dedík, L

机构：

[1] Slovak Acad Sci, Inst Expt Pharmacol, Bratislava 84104, Slovakia

[2] Slovak Univ Technol Bratislava, Fac Mech Engn, Bratislava 81231, Slovakia

来源：

JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS | 2002年 / 29卷 / 5-6期

关键词：

pharmacokinetics; dosage adjustment; computer simulation; system approach; Factor VIII; hemophilia A;

D O I：

10.1023/A:1022968319095

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The aim of this simulation study was to present a system-approach method for adjustment of continuous drug infusions at time-varying rates, aimed at achieving and then maintaining required drug concentration-time profiles in patients. The method presented can be used for safe and cost-effective individualization of drug dosing by computer-controlled infusion pumps. Utilization of this method is exemplified by simulation experiments, aimed at adjusting continuous infusions of Factor VIII (FVIII) at time-varying rates, which would theoretically yield required concentration-time profiles of FVIII in hemophilia A patients over several days.

引用

页码：427 / 444

页数：18

共 39 条

[1]

[Anonymous], SYSTEMS CONTROL ENCY

[2]

The pharmacokinetics of factor VIII and factor IX: Methodology, pitfalls and applications [J].