Role of peroxisome proliferator-activated receptor α in disease of pancreatic β cells

被引：160

作者：

Zhou, YT

Shimabukuro, M

Wang, MY

Lee, Y

Higa, M

Milburn, JL

Newgard, CB

Unger, RH

机构：

[1] Univ Texas, SW Med Sch, Gifford Labs Diabet Res, Ctr Diabet Res, Dallas, TX 75235 USA

[2] Univ Texas, SW Med Sch, Dept Internal Med, Dallas, TX 75235 USA

[3] Univ Texas, SW Med Sch, Dept Biochem, Dallas, TX 75235 USA

[4] Vet Affairs Med Ctr, Dallas, TX 75216 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 15期

关键词：

D O I：

10.1073/pnas.95.15.8898

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Expression of peroxisome proliferator-activated receptor alpha(PPAR alpha) and enzymes of fatty acid (FA) oxidation is markedly reduced in the fat-laden, dysfunctional islets of obese, prediabetic Zucker diabetic fatty (fa/fa) rats with mutated leptin receptors (OB-R). Leptin, PPAR alpha/ retinoid x receptor ligands, and FA all up-regulate PPAR alpha and enzymes of FA oxidation and stimulate [H-3]-palmitate oxidation in normal islets but not in islets from fa/fa rats. Overexpression of normal OB-R in islets of fa/fa rats corrects all of the foregoing abnormalities and reverses the diabetic phenotype. PPAR alpha is a OB-R-dependent factor required for normal fat homeostasis in islet cells.

引用

收藏

页码：8898 / 8903

页数：6

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