Glycoprotein Ibα and von Willebrand factor in primary platelet adhesion and thrombus formation:: Lessons from mutant mice

被引:66
作者
Bergmeier, Wolfgang [1 ,2 ]
Chauhan, Anil K. [3 ,4 ]
Wagner, Denisa D. [3 ,4 ]
机构
[1] Thomas Jefferson Univ, Cardeza Fdn Hematol Res, Philadelphia, PA 19007 USA
[2] Thomas Jefferson Univ, Dept Med, Philadelphia, PA 19007 USA
[3] Harvard Univ, Sch Med, Immune Dis Inst, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
关键词
thrombosis; glycoprotein; von Willebrand factor; mutant; mice;
D O I
10.1160/TH07-10-0638
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The von Willebrand factor (VWF) receptor complex, glycoprotein (GP)Ib-V-IX, and its main ligand VWF play a key role in the adhesion process of platelets to sites of vascular injury. Recent studies in mutant mice have shed new light on the importance of either molecule for the development of arterial and venous thrombosis. In this review, we summarize the most important aspects from these studies.
引用
收藏
页码:264 / 270
页数:7
相关论文
共 74 条
[1]   The glycoprotein Ib-IX-V complex in platelet adhesion and signaling [J].
Andrews, RK ;
Shen, Y ;
Gardiner, EE ;
Dong, JF ;
López, JA ;
Berndt, MC .
THROMBOSIS AND HAEMOSTASIS, 1999, 82 (02) :357-364
[2]   Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex:: studies using optical tweezers [J].
Arya, M ;
Anvari, B ;
Romo, GM ;
Cruz, MA ;
Dong, JF ;
McIntire, LV ;
Moake, JL ;
López, JA .
BLOOD, 2002, 99 (11) :3971-3977
[3]  
BADIMON L, 1989, BLOOD, V73, P961
[4]   RETRACTED: Factor XI binding to the platelet glycoprotein Ib-IX-V complex promotes factor XI activation by thrombin (Retracted Article. See vol 282, pg 29067, 2007) [J].
Baglia, FA ;
Badellino, KO ;
Li, CQ ;
López, JA ;
Walsh, PN .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (03) :1662-1668
[5]   Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura [J].
Banno, F ;
Kokame, K ;
Okuda, T ;
Honda, S ;
Miyata, S ;
Kato, H ;
Tomiyama, Y ;
Miyata, T .
BLOOD, 2006, 107 (08) :3161-3166
[6]   Structural and functional characterization of the mouse von Willebrand factor receptor GPIb-IX with novel monoclonal antibodies [J].
Bergmeier, W ;
Rackebrandt, K ;
Schröder, W ;
Zirngibl, H ;
Nieswandt, B .
BLOOD, 2000, 95 (03) :886-893
[7]   The role of platelet adhesion receptor GPIbα far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis [J].
Bergmeier, Wolfgang ;
Piffath, Crystal L. ;
Goerge, Tobias ;
Cifuni, Stephen M. ;
Ruggeri, Zaverio M. ;
Ware, Jerry ;
Wagner, Denisa D. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (45) :16900-16905
[8]  
BERNARD J, 1948, Sem Hop, V24, P3217
[9]   AURIN TRICARBOXYLIC-ACID INHIBITS EXPERIMENTAL VENOUS THROMBOSIS [J].
BERNAT, A ;
LALE, A ;
HERBERT, JM .
THROMBOSIS RESEARCH, 1994, 74 (06) :617-627
[10]   Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13 [J].
Bonnefoy, A ;
Daenens, K ;
Feys, HB ;
De Vos, R ;
Vandervoort, P ;
Vermylen, J ;
Lawler, J ;
Hoylaerts, MF .
BLOOD, 2006, 107 (03) :955-964