Glycoprotein Ibα and von Willebrand factor in primary platelet adhesion and thrombus formation:: Lessons from mutant mice

被引：66

作者：

Bergmeier, Wolfgang ^{[1
,2
]}

Chauhan, Anil K. ^{[3
,4
]}

Wagner, Denisa D. ^{[3
,4
]}

机构：

[1] Thomas Jefferson Univ, Cardeza Fdn Hematol Res, Philadelphia, PA 19007 USA

[2] Thomas Jefferson Univ, Dept Med, Philadelphia, PA 19007 USA

[3] Harvard Univ, Sch Med, Immune Dis Inst, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

THROMBOSIS AND HAEMOSTASIS | 2008年 / 99卷 / 02期

关键词：

thrombosis; glycoprotein; von Willebrand factor; mutant; mice;

D O I：

10.1160/TH07-10-0638

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The von Willebrand factor (VWF) receptor complex, glycoprotein (GP)Ib-V-IX, and its main ligand VWF play a key role in the adhesion process of platelets to sites of vascular injury. Recent studies in mutant mice have shed new light on the importance of either molecule for the development of arterial and venous thrombosis. In this review, we summarize the most important aspects from these studies.

引用

页码：264 / 270

页数：7

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