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Immune regulatory loops determine productive interactions within human T lymphocyte dendritic cell clusters

被引：35
作者：
Stuhler, G
Zobywalski, A
Grünebach, F
Brossart, P
Reichardt, VL
Barth, H
Stevanovic, S
Brugger, W
Kanz, L
Schlossman, SF
机构：
[1] Dana Farber Canc Inst, Div Tumor Immunol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA 02115 USA
[3] Univ Tubingen, Med Clin 2, D-72076 Tubingen, Germany
[4] Inst Cell Biol, Dept Immunol, D-72076 Tubingen, Germany
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1999年 / 96卷 / 04期
关键词：
D O I：
10.1073/pnas.96.4.1532
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Help for the induction of cytolytic T lymphocytes is mediated by dendritic cells (DC) that are conditioned by CD40 signaling. We identified tumor necrosis factor family member CD27L/CD70, which is expressed by cytolytic T lymphocytes on interaction with DC to control CD154 (CD40L) up-regulation on CD45RA(+) helper T cells for subsequent DC stimulation. The results show that the initiation of a cytolytic Immune response is determined by regulatory circuits, requiring simultaneous activation and differentiation of ail cells involved in T lymphocyte-DC cluster formation.
引用
收藏
页码：1532 / 1535
页数：4
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