Immune regulatory loops determine productive interactions within human T lymphocyte dendritic cell clusters

被引：35

作者：

Stuhler, G

Zobywalski, A

Grünebach, F

Brossart, P

Reichardt, VL

Barth, H

Stevanovic, S

Brugger, W

Kanz, L

Schlossman, SF

机构：

[1] Dana Farber Canc Inst, Div Tumor Immunol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Univ Tubingen, Med Clin 2, D-72076 Tubingen, Germany

[4] Inst Cell Biol, Dept Immunol, D-72076 Tubingen, Germany

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1999年 / 96卷 / 04期

关键词：

D O I：

10.1073/pnas.96.4.1532

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Help for the induction of cytolytic T lymphocytes is mediated by dendritic cells (DC) that are conditioned by CD40 signaling. We identified tumor necrosis factor family member CD27L/CD70, which is expressed by cytolytic T lymphocytes on interaction with DC to control CD154 (CD40L) up-regulation on CD45RA(+) helper T cells for subsequent DC stimulation. The results show that the initiation of a cytolytic Immune response is determined by regulatory circuits, requiring simultaneous activation and differentiation of ail cells involved in T lymphocyte-DC cluster formation.

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收藏

页码：1532 / 1535

页数：4

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