Facile and general synthesis of quaternary 3-aminooxindoles

被引：103

作者：

Marsden, Stephen P. ^{[1
]}

Watson, Emma L. ^{[1
]}

Raw, Steven A. ^{[2
]}

机构：

[1] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England

[2] AstraZeneca Proc R&D, Macclesfield SK10 2NA, Cheshire, England

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 13期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/ol801028e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel approach to the valuable quaternary 3-aminooxindole skeleton is reported on the basis of intramolecular arylation of enolates of substituted amino acids. The reaction tolerates dialkyl- and arylalkylamines as well as a range of carbon substituents (primary and secondary alkyl, aryl). The cyclization of N-indolyl-substituted substrates is accompanied by direct C-H arylation of the indole, leading to indolo-fused benzodiazepines.

引用

页码：2905 / 2908

页数：4

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