5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa

被引：27

作者：

Batt, DG ^{[1
]}

Qiao, JX ^{[1
]}

Modi, DP ^{[1
]}

Houghton, GC ^{[1
]}

Pierson, DA ^{[1
]}

Rossi, KA ^{[1
]}

Luettgen, JM ^{[1
]}

Knabb, RM ^{[1
]}

Jadhav, PK ^{[1
]}

Wexler, RR ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NJ 08543 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 21期

关键词：

factor IXa; anticoagulant; indole;

D O I：

10.1016/j.bmcl.2004.08.037

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structural features of a 5-amidinoindole inhibitor of factor Xa, which displayed modest inhibition of factor IXa were varied to increase potency and improve selectivity for factor IXa. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5269 / 5273

页数：5

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