The Ca2+/Mn2+ pumps in the Golgi apparatus

被引：101

作者：

Van Baelen, K ^{[1
]}

Dode, L ^{[1
]}

Vanoevelen, J ^{[1
]}

Callewaert, G ^{[1
]}

De Smedt, H ^{[1
]}

Missiaen, L ^{[1
]}

Parys, JB ^{[1
]}

Raeymaekers, L ^{[1
]}

Wuytack, F ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Fysiol Lab, B-3000 Louvain, Belgium

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1742卷 / 1-3期

关键词：

Golgi; SPCA1; SERCA; Hailey-Hailey; calcium; manganese;

D O I：

10.1016/j.bbamcr.2004.08.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent evidence highlights the functional importance of the Golgi apparatus as an agonist-sensitive intracellular Ca2+ store. Besides Ca2+-release channels and Ca2+-binding proteins, the Golgi complex contains Ca2+-uptake mechanisms consisting of the well-known sarco/endoplasmic reticulum Ca2+-transport ATPases (SERCA) and the much less characterized secretory-pathway Ca2+-transport ATPases (SPCA). SPCA supplies the Golgi compartments and, possibly, the more distal compartments of the secretory pathway with both Ca2+ and Mn2+ and, therefore, plays an important role in the cytosolic and intra-Golgi Ca2+ and Mn2+ homeostasis. Mutations in the human gene encoding the SPCA1 pump (ATP2C1) resulting in Hailey-Hailey disease, an autosomal dominant skin disorder, are discussed. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：103 / 112

页数：10

共 99 条

[1] THE YEAST CA-2+-ATPASE HOMOLOG, PMR1, IS REQUIRED FOR NORMAL GOLGI FUNCTION AND LOCALIZES IN A NOVEL GOLGI-LIKE DISTRIBUTION [J].

ANTEBI, A ;

FINK, GR .

MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (06) :633-654

[2] Actin reorganization is abnormal and cellular ATP is decreased in Hailey-Hailey keratinocytes [J].

Aronchik, I ;

Behne, MJ ;

Leypoldt, L ;

Crumrine, D ;

Epstein, E ;

Ikeda, S ;

Mizoguchi, M ;

Bench, G ;

Pozzan, T ;

Mauro, T .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2003, 121 (04) :681-687

[3] ON THE FIDELITY OF DNA-REPLICATION - MANGANESE MUTAGENESIS INVITRO [J].

BECKMAN, RA ;

MILDVAN, AS ;

LOEB, LA .

BIOCHEMISTRY, 1985, 24 (21) :5810-5817

[4] Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores [J].

Behne, MJ ;

Tu, CL ;

Aronchik, I ;

Epstein, E ;

Bench, G ;

Bikle, DD ;

Pozzan, T ;

Mauro, TM .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2003, 121 (04) :688-694

[5] INOSITOL TRISPHOSPHATE AND CALCIUM SIGNALING [J].

BERRIDGE, MJ .

NATURE, 1993, 361 (6410) :315-325

[6] Inhibition of reverse transcription in vivo by elevated manganese ion concentration [J].

Bolton, EC ;

Mildvan, AS ;

Boeke, JD .

MOLECULAR CELL, 2002, 9 (04) :879-889

[7] Similar Ca2+-signaling properties in keratinocytes and in COS-1 cells overexpressing the secretory-pathway Ca2+-ATPase SPCA1 [J].

Callewaert, G ;

Parys, JB ;

De Smedt, H ;

Raeymaekers, L ;

Wuytack, F ;

Vanoevelen, J ;

Van Baelen, K ;

Simoni, A ;

Rizzuto, R ;

Missiaen, L .

CELL CALCIUM, 2003, 34 (02) :157-162

[8] TRANSPORT VIA THE REGULATED SECRETORY PATHWAY IN SEMIINTACT PC12 CELLS - ROLE OF INTRA-CISTERNAL CALCIUM AND PH IN THE TRANSPORT AND SORTING OF SECRETOGRANIN-II [J].

CARNELL, L ;

MOORE, HPH .

JOURNAL OF CELL BIOLOGY, 1994, 127 (03) :693-705

[9] STIMULATION OF PROTEIN-KINASE-C DURING CA2+-INDUCED KERATINOCYTE DIFFERENTIATION - SELECTIVE BLOCKADE OF MARCKS PHOSPHORYLATION BY CALMODULIN [J].

CHAKRAVARTHY, BR ;

ISAACS, RJ ;

MORLEY, P ;

DURKIN, JP ;

WHITFIELD, JF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (03) :1362-1368

[10] MILIEU-INDUCED, SELECTIVE AGGREGATION OF REGULATED SECRETORY PROTEINS IN THE TRANS-GOLGI NETWORK [J].

CHANAT, E ;

HUTTNER, WB .

JOURNAL OF CELL BIOLOGY, 1991, 115 (06) :1505-1519

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