Defining the risks of mesenchymal stromal cell therapy

被引：263

作者：

Prockop, Darwin J. ^{[1
]}

Brenner, Malcolm ^{[2
]}

Fibbe, Willem E. ^{[3
]}

Horwitz, Edwin ^{[4
]}

Le Blanc, Katarina ^{[5
]}

Phinney, Donald G. ^{[6
]}

Simmons, Paul J. ^{[7
]}

Sensebe, Lug ^{[8
]}

Keating, Armand ^{[9
]}

机构：

[1] Texas A&M Hlth Sci Coll Med, Inst Regenerat Med Scott & White, Temple, TX 76502 USA

[2] Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

[3] Leiden Univ, Med Ctr, Leiden, Netherlands

[4] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

[5] Karolinska Inst, Stockholm, Sweden

[6] Scripps Res Inst, Dept Mol Therapeut, Jupiter, FL USA

[7] Univ Texas Hlth Sci Ctr, Ctr Stem Cell Res, Houston, TX USA

[8] Med & Sci EFS Ctr Atlantique, Tours, France

[9] Princess Margaret Hosp, Toronto, ON M4X 1K9, Canada

来源：

CYTOTHERAPY | 2010年 / 12卷 / 05期

关键词：

MSCs; mesenchymal stem cells; cell contamination; STEM-CELLS; TRANSFORMATION; CULTURE; FIBROBLASTS; SENESCENCE;

D O I：

10.3109/14653249.2010.507330

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

We address the issue of the potential for malignant transformation of cultured mesenchymal stromal cells (MSC) commonly used in clinical cell-therapy protocols and describe the culture conditions under which tumorigenesis is likely to be an extremely uncommon event.

引用

页码：576 / 578

页数：3

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