Complex trait analysis in the mouse: The strengths, the limitations and the promise yet to come

被引：78

作者：

Moore, KJ ^{[1
]}

Nagle, DL ^{[1
]}

机构：

[1] Hypnion Inc, Worcester, MA 01605 USA

来源：

ANNUAL REVIEW OF GENETICS | 2000年 / 34卷

关键词：

quantitative trait; genetics; mouse;

D O I：

10.1146/annurev.genet.34.1.653

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In 1990, David Baltimore predicted that the 1990s would be the decade of the mouse (1). This certainly proved to be true: The mouse has contributed immensely to biological research through transgenic, embryonic stem cell (ES) knockout, and classical genetic technologies. But its usefulness as a model organism is by no means over; indeed it is still rising to its peak: The mouse as a model mammalian organism still has much to offer. This article reviews use of the mouse to dissect complex genetic traits using quantitative trait analysis, with a particular emphasis on medically important diseases.

引用

页码：653 / 686

页数：38

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[91] Mechanisms of disease - Atherosclerosis - An inflammatory disease [J].