CD30 ligand is expressed on resting normal and malignant human B lymphocytes

CD30, a member of the tumour necrosis receptor superfamily, is physiologically expressed on a subpopulation of T helper cells in normal individuals but is also expressed on several malignant and virally transformed cells, Its ligand (CD30L) is a pleiotropic cellular transmembrane protein that can induce cell death in several CD30(+) cell lines. CD30L expression has been reported on activated human peripheral blood T lymphocytes and macrophages but not on B cells. Here we show that the CD30L is ex-pressed on resting normal and on malignant B cells in addition to both CD4(+) and CD8(+) subsets of activated T cells, making it the second tumour necrosis family member, in addition to the CD27 ligand, that can be expressed on both T and B cells. These findings raise the possibility that the CD30L has a role in B-cell/T-cell communication and that B and T cells are likely to be involved in the growth regulation of CD30(+) tumours.