共 41 条
One-pot synthesis of polysubstituted pyrrolidines from aminonitriles
被引:36
作者:
Meyer, N
[1
]
Werner, F
[1
]
Opatz, T
[1
]
机构:
[1] Univ Mainz, Inst Organ Chem, D-55128 Mainz, Germany
来源:
SYNTHESIS-STUTTGART
|
2005年
/
06期
关键词:
pyrrolidines;
aminonitriles;
Michael additions;
reductions;
combinatorial chemistry;
D O I:
10.1055/s-2005-861838
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
alpha-Aminonitriles with a mono- or unsubstituted amino group as well as alpha(alkylideneaminomitriles can be employed as easily accessible alpha-aminocarbanion equivalents. Their alpha-deprotonation yields stabilized carbanions, which undergo smooth 1,4-addition to alpha,beta-unsaturated carbonyl compounds. The resulting delta-keto-alpha-aminonitriles can be reductively cyclized to form polysubstituted pyrrolidines.
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页码:945 / 956
页数:12
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