Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome

被引:169
作者
Alcocer-Gomez, Elisabet [1 ,2 ]
Ulecia-Moron, Cristina [3 ]
Marin-Aguilar, Fabiola [4 ]
Rybkina, Tatyana [3 ]
Casas-Barquero, Nieves [5 ]
Ruiz-Cabello, Jesus [6 ,7 ,8 ]
Ryffel, Bernhard [9 ]
Apetoh, Lionel [10 ,11 ,12 ]
Ghiringhelli, Francois [10 ,11 ,12 ]
Bullon, Pedro [4 ]
Antonio Sanchez-Alcazar, Jose [1 ,2 ]
Carrion, Angel M. [3 ]
Cordero, Mario D. [4 ,13 ,14 ]
机构
[1] Univ Pablo de Olavide CSIC Junta de Andalucia, CABD, Seville 41013, Spain
[2] ISCIII, CIBERER, Seville 41013, Spain
[3] Univ Pablo de Olavide Sevilla, Dept Fisiol Anat & Biol Celular, Carretera Utrera Km 1, Seville 41013, Spain
[4] Univ Seville, Sch Dent, Res Lab, Seville, Spain
[5] Univ Seville, Fac Med, Hosp Univ Virgen Macarena, Dept Psiquiatria, Seville, Spain
[6] CIBER Enfermedades Resp, Madrid, Spain
[7] Ctr Nacl Invest Cardiovasc, Adv Imaging Unit, Madrid, Spain
[8] Univ Complutense Madrid, Madrid, Spain
[9] CNRS, UMR7355, Orleans, France
[10] INSERM, UMR866, Dijon, France
[11] Ctr Georges Francois Leclerc, Dijon, France
[12] Univ Bourgogne, Dijon, France
[13] Univ Seville Spain, CSIC, Univ Hosp Virgen del Rocio, IBiS Inst Biomed Seville, Seville, Spain
[14] Univ Seville, IBiS Inst Biomed Seville, C Calle Antonio Maura Montaner S-N, Seville 41013, Spain
关键词
Stress; Depression; Inflammasome; Microglia; HIPPOCAMPAL NEUROGENESIS; MAJOR DEPRESSION; MICROGLIA; ACTIVATION; BRAIN; MEDIATOR; PATHWAY;
D O I
10.1007/s12035-015-9408-7
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Depression is a major public health concern in modern society, yet little is known about the molecular link between this condition and neuroinflammation. The inflammasome complex was recently shown to be implicated in depression. The present study shows the implication of NLRP3 inflammasome in animal model of stress-induced depression. Accordingly, we show here that in the absence of a NLRP3 inflammasome, prolonged stress does not provoke depressive behaviors or microglial activation in mice or dampen hippocampal neurogenesis. Indeed, NLRP3 deletion or inhibition of microglial activation impairs the stress-induced alterations associated with depression. According to these findings in animal model, the inflammasome could be a target for new therapeutic interventions to prevent depression in patients.
引用
收藏
页码:4874 / 4882
页数:9
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