Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof-of-concept trial in physically injured patients

被引：146

作者：

Stein, Murray B. ^{[1
,2
,4
]}

Kerridge, Carol ^{[1
]}

Dimsdale, Joel E. ^{[1
]}

Hoyt, David B. ^{[3
]}

机构：

[1] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA

[2] VA San Diego Healthcare Syst, San Diego, CA USA

[3] Univ Calif Irvine, Dept Surg, Div Trauma, Irvine, CA 92717 USA

[4] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA

来源：

JOURNAL OF TRAUMATIC STRESS | 2007年 / 20卷 / 06期

关键词：

D O I：

10.1002/jts.20270

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Acute physical injury is frequently associated with mental health sequelae, which then accentuate disability and worsen functional outcomes. A pharmacological prevention approach to this problem has been proposed. This proof-of-concept study was a double-blind, randomized controlled trial of 14 days of the beta-blocker propranolol (n = 17), the anxiolytic anticonvulsant gabapentin (n = 14), or placebo (n = 17), administered within 48 hours of injury to patients admitted to a surgical trauma center. Of 569 accessible, potentially eligible subjects, 48 (8%) participated. Outcomes assessments were conducted at 1, 4 and 8 months postinjury. Although well tolerated, neither study drug showed a significant benefit over placebo on depressive or posttraumatic stress symptoms. Implications are discussed for future pharmacological prevention studies in survivors of acute traumatic injury.

引用

页码：923 / 932

页数：10

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