Reactive oxygen species produced upon photoexcitation of sunscreens containing titanium dioxide (an EPR study)

被引:159
作者
Brezová, V [1 ]
Gabcová, S [1 ]
Dvoranová, D [1 ]
Stasko, A [1 ]
机构
[1] Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Dept Phys Chem, SK-81237 Bratislava, Slovakia
关键词
sunscreen; sun protection factor; titanium dioxide; free radicals; reactive oxygen species; singlet oxygen; EPR spectroscopy; spin trapping technique; TEMPOL;
D O I
10.1016/j.jphotobiol.2004.12.006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Commercial sunscreen products containing titanium dioxide were irradiated with lambda > 300 nm and the formation of oxygen-((OH)-O-center dot, O-2(center dot-)/(OOH)-O-center dot) and carbon-centered radicals was monitored by EPR spectroscopy and spin trapping technique using 5,5dimethyl-1-pyrroline N-oxide, alpha-phenyl-N-tert-butylnitrone (PBN), alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone as spin traps, and free nitroxide radical 4-hydroxy-2,2,6,6-tetramethylpiperidine N-oxyl. The photoinduced production of singlet oxygen was shown by 4-hydroxy-2,2,6,6-piperidine. The generation of reactive oxygen radical species upon irradiation of sunscreens significantly depends on their composition, as the additives present (antioxidants, radical-scavengers, solvents) can transform the reactive radicals formed to less harmful products. The continuous in situ irradiation of titanium dioxide powder, recommended for cosmetic application, investigated in different solvents (water, dimethyl sulfoxide, isopropyl myristate) resulted in the generation of oxygen-centered reactive radical species (superoxide anion radical, hydroxyl and alkoxyl radicals). (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:121 / 134
页数:14
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