The Complexity of Antibody-Dependent Enhancement of Dengue Virus Infection

被引：110

作者：

Guzman, Maria G. ^{[1
]}

Vazquez, Susana ^{[1
]}

机构：

[1] Pedro Kouri Trop Med Inst Havana, PAHO WHO Collaborating Ctr Study Dengue & Vector, Dept Virol, Havana, Cuba

来源：

VIRUSES-BASEL | 2010年 / 2卷 / 12期

关键词：

dengue; dengue hemorrhagic fever; prM; ADE; neutralization; cleavage; BORNE ENCEPHALITIS-VIRUS; HEMORRHAGIC-FEVER; MONOCLONAL-ANTIBODIES; NEUTRALIZING ANTIBODY; ENVELOPE GLYCOPROTEIN; FLAVIVIRUS INFECTION; PRM PROTEIN; CUBAN POPULATION; DISEASE SEVERITY; IMMUNE-RESPONSE;

D O I：

10.3390/v2122649

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antibody-dependent enhancement (ADE) has been proposed as a mechanism to explain dengue hemorrhagic fever (DHF) in the course of a secondary dengue infection. Very recently, Dejnirattisai et al., 2010 [1], published an important article supporting the involvement of anti-prM antibodies in the ADE phenomenon. The complexity of ADE in the context of a secondary dengue infection is discussed here.

引用

页码：2649 / 2662

页数：14

共 97 条

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