The indium-mediated selective introduction of allenyl and propargyl groups at the C4-position of 2-azetidinones and the AuCl3-catalyzed cyclization of 4-allenyl-2-azetidinones

被引：71

作者：

Lee, PH ^{[1
]}

Kim, H ^{[1
]}

Lee, K ^{[1
]}

Kim, M ^{[1
]}

Noh, K ^{[1
]}

Kim, H ^{[1
]}

Seomoon, D ^{[1
]}

机构：

[1] Kangwon Natl Univ, Dept Chem, Chunchon 200701, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 12期

关键词：

allenylation; cyclization; gold; indium; lactams;

D O I：

10.1002/anie.200462512

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Bicyclic β lactams are obtained by the two-step procedure shown in the scheme. Alternatively, with the help of organoindium reagents, allenyl and propargyl groups are introduced at the C4-position of 2-azetidinones. R1 = H, 1R-(tert-butyl- dimethylsilyloxy)ethyl (TBSO(CH3)CH); R2= H, methyl, ethyl, n-butyl, phenyl, THPOCH2, trimethylsilyl, 2-naphthyl; R 3 = H, methyl, phenyl; R4 = H, methyl. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1840 / 1843

页数：4

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