SIRT1: recent lessons from mouse models

被引：232

作者：

Herranz, Daniel ^{[1
]}

Serrano, Manuel ^{[1
]}

机构：

[1] Spanish Natl Canc Res Ctr CNIO, Tumour Suppress Grp, E-28029 Madrid, Spain

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 12期

基金：

欧洲研究理事会;

关键词：

LIFE-SPAN; CALORIE RESTRICTION; SACCHAROMYCES-CEREVISIAE; METABOLIC DISEASE; INCREASED DOSAGE; CELL-SURVIVAL; RESVERATROL; SIRTUINS; ACTIVATION; PROTECTS;

D O I：

10.1038/nrc2962

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The family of protein deacetylases represented by yeast Sir2 has been the focus of intense investigation because of the longevity activity of Sir2 in yeast, worms and flies. Research in mammals has mainly focused on SIRT1, the closest homologue of Sir2. Emerging evidence from mouse models is yielding a sharper picture, in which SIRT1 is a potent protector from ageing-associated pathologies, such as diabetes, liver steatosis, cardiovascular disease, neurodegeneration and, importantly, various types of cancer.

引用

页码：819 / 823

页数：5

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