Three new phenolic glycosides from Curculigo orchioides G.

被引：44

作者：

Zuo, Ai-Xue ^{[1
,3
]}

Shen, Yong ^{[1
,3
]}

Jiang, Zhi-Yong ^{[1
]}

Zhang, Xue-Mei ^{[1
]}

Zhou, Jun ^{[1
]}

Lue, Jun ^{[2
]}

Chen, Ji-Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China

[2] Kunming Jingbiao Biosci R&D Co Ltd, Kunming 650000, Yunnan, Peoples R China

[3] Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China

来源：

FITOTERAPIA | 2010年 / 81卷 / 07期

关键词：

Curculigosides F-H; Phenolic glycoside; Anti-HBV; Curculigo orchioides; ALKALOIDS; RHIZOMES; EXTRACT;

D O I：

10.1016/j.fitote.2010.06.003

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Three new phenolic glycosides, curculigosides F-H (1-3), were isolated from rhizomes of Curculigo orchioides Gaertn. Their structures were elucidated based on comprehensive spectroscopic analyses including IR, MS, 1D- and 2D NMR (HSQC, COSY, and HMBC). Curculigosides F-H (1-3) were evaluated for their anti-HBV activity in vitro using the HBV transfected Hep G2.2.15 cell line. Compound 1 exhibited weak activity with an IC(50) value of 2.08 mM on hepatitis B virus (HBV) e antigen (HBeAg) secretion of the HepG2.2.15 cell line. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：910 / 913

页数：4

共 15 条

[1]

Immunostimulatory effect of methanol extract of Curculigo orchioides on immunosuppressed mice [J].