Molecular mechanisms of dendritic spine development and remodeling

被引:274
作者
Ethell, IM
Pasquale, EB
机构
[1] Burnham Inst, La Jolla, CA 92037 USA
[2] Univ Calif Riverside, Div Biomed Sci, Riverside, CA 92521 USA
[3] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA
关键词
D O I
10.1016/j.pneurobio.2005.02.003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Dendritic spines are small protrusions that cover the surface of dendrites and bear the postsynaptic component of excitatory synapses. Having an enlarged head connected to the dendrite by a narrow neck, dendritic spines provide a postsynaptic biochemical compartment that separates the synaptic space from the dendritic shaft and allows each spine to function as a partially independent unit. Spines develop around the time of synaptogenesis and are dynamic structures that continue to undergo remodeling over time. Changes in spine morphology and density influence the properties of neural circuits. Our knowledge of the structure and function of dendritic spines has progressed significantly since their discovery over a century ago, but many uncertainties still remain. For example, several different models have been put forth outlining the sequence of events that lead to the genesis of a spine. Although spines are small and apparently simple organelles with a cytoskeleton mainly composed of actin filaments, regulation of their morphology and physiology appears to be quite sophisticated. A multitude of molecules have been implicated in dendritic spine development and remodeling, suggesting that intricate networks of interconnected signaling pathways converge to regulate actin dynamics in spines. This complexity is not surprising, given the likely importance of dendritic spines in higher brain functions. In this review, we discuss the molecules that are currently known to mediate the exquisite sensitivity of spines to perturbations in their environment and we outline how these molecules interface with each other to mediate cascades of signals flowing from the spine surface to the actin cytoskeleton. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:161 / 205
页数:45
相关论文
共 575 条
[51]   IDENTIFICATION OF FODRIN AS A MAJOR CALMODULIN-BINDING PROTEIN IN POSTSYNAPTIC DENSITY PREPARATIONS [J].
CARLIN, RK ;
BARTELT, DC ;
SIEKEVITZ, P .
JOURNAL OF CELL BIOLOGY, 1983, 96 (02) :443-447
[52]   ISOLATION AND CHARACTERIZATION OF POSTSYNAPTIC DENSITIES FROM VARIOUS BRAIN-REGIONS - ENRICHMENT OF DIFFERENT TYPES OF POSTSYNAPTIC DENSITIES [J].
CARLIN, RK ;
GRAB, DJ ;
COHEN, RS ;
SIEKEVITZ, P .
JOURNAL OF CELL BIOLOGY, 1980, 86 (03) :831-843
[53]   ACTIN POLYMERIZABILITY IS INFLUENCED BY PROFILIN, A LOW-MOLECULAR WEIGHT PROTEIN IN NON-MUSCLE CELLS [J].
CARLSSON, L ;
NYSTROM, LE ;
SUNDKVIST, I ;
MARKEY, F ;
LINDBERG, U .
JOURNAL OF MOLECULAR BIOLOGY, 1977, 115 (03) :465-483
[54]   Chromosomal anomalies in individuals with autism - A strategy towards the identification of genes involved in autism [J].
Castermans, D ;
Wilquet, V ;
Steyaert, J ;
van de Ven, W ;
Fryns, JP ;
Devriendt, K .
AUTISM, 2004, 8 (02) :141-161
[55]  
Celio M R, 1999, J Hist Neurosci, V8, P186, DOI 10.1076/jhin.8.2.186.1832
[56]   TRANSIENT AND ENDURING MORPHOLOGICAL CORRELATES OF SYNAPTIC ACTIVITY AND EFFICACY CHANGE IN THE RAT HIPPOCAMPAL SLICE [J].
CHANG, FLF ;
GREENOUGH, WT .
BRAIN RESEARCH, 1984, 309 (01) :35-46
[57]   Distribution of p120 catenin during rat brain development: potential role in regulation of cadherin-mediated adhesion and actin cytoskeleton organization [J].
Chauvet, N ;
Prieto, M ;
Fabre, C ;
Noren, NK ;
Privat, A .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2003, 22 (04) :467-486
[58]   Integrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse [J].
Chavis, P ;
Westbrook, G .
NATURE, 2001, 411 (6835) :317-321
[59]   A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II [J].
Chen, HJ ;
Rojas-Soto, M ;
Oguni, A ;
Kennedy, MB .
NEURON, 1998, 20 (05) :895-904
[60]   Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms [J].
Chen, L ;
Chetkovich, DM ;
Petralia, RS ;
Sweeney, NT ;
Kawasaki, Y ;
Wenthold, RJ ;
Bredt, DS ;
Nicoll, RA .
NATURE, 2000, 408 (6815) :936-943