Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3

被引：153

作者：

Barbui, Tiziano ^{[1
]}

Carobbio, Alessandra

Finazzi, Guido

Vannucchi, Alessandro M. ^{[2
,3
]}

Barosi, Giovanni ^{[4
,5
]}

Antonioli, Elisabetta ^{[2
,3
]}

Guglielmelli, Paola ^{[2
,3
]}

Pancrazzi, Alessandro ^{[2
,3
]}

Salmoiraghi, Silvia

Zilio, Pio ^{[6
]}

Ottomano, Cosimo ^{[6
]}

Marchioli, Roberto ^{[7
]}

Cuccovillo, Ivan ^{[8
]}

Bottazzi, Barbara ^{[8
]}

Mantovani, Alberto ^{[8
,9
]}

Rambaldi, Alessandro

机构：

[1] Osped Riuniti Bergamo, Div Ematol, Dept Hematol, I-24128 Bergamo, Italy

[2] Univ Florence, Dipartimento Area Crit, Unita Funz Ematol, Florence, Italy

[3] Ist Toscano Tumori, Florence, Italy

[4] Policlin S Matteo Fdn, IRCCS, Clin Epidemiol Unit, Pavia, Italy

[5] Policlin S Matteo Fdn, IRCCS, Ctr Study Myelofibrosis, Pavia, Italy

[6] Osped Riuniti Bergamo, Clin Chem Lab, I-24128 Bergamo, Italy

[7] Consorzio Mario Negri Sud, Lab Clin Epidemiol Cardiovasc Dis, Santa Maria Imbaro, CH, Italy

[8] IRCCS, Ist Clin Humanitas, Lab Immunol & Inflammat, Milan, Italy

[9] Univ Milan, Dipartimento Med Traslaz, Milan, Italy

来源：

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2011年 / 96卷 / 02期

关键词：

essential thrombocythemia; polycythemia vera; C-reactive protein; pentraxin; 3; ACUTE MYOCARDIAL-INFARCTION; MYELOPROLIFERATIVE DISORDERS; PTX3; RISK; LEUKOCYTOSIS; MUTATION; DISEASE;

D O I：

10.3324/haematol.2010.031070

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We tested the hypothesis that levels of pentraxin high sensitivity C-reactive protein and pentraxin 3 might be correlated with cardiovascular complications in patients with essential thrombocythemia and polycythemia vera. High sensitivity C-reactive protein and pentraxin 3 were measured in 244 consecutive essential thrombocythemia and polycythemia vera patients in whom, after a median follow up of 5.3 years (range 0-24), 68 cardiovascular events were diagnosed. The highest C-reactive protein tertile was compared with the lowest (> 3 vs. < 1 mg/L) and correlated with age (P=0.001), phenotype (polycythemia vera vs. essential thrombocythemia, P=0.006), cardiovascular risk factors (P=0.012) and JAK2V617F allele burden greater than 50% (P=0.003). Major thrombosis rate was higher in the highest C-reactive protein tertile (P=0.01) and lower at the highest pentraxin 3 levels (P=0.045). These associations remained significant in multivariate analyses and indicate that blood levels of high sensitivity C-reactive protein and petraxin 3 independently and in opposite ways modulate the intrinsic risk of cardiovascular events in patients with myeloproliferative disorders.

引用

页码：315 / 318

页数：4

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