Selective breeding of two rat lines differing in sensitivity to GHB and baclofen

被引：11

作者：

Colombo, G

Lobina, C

Agabio, R

Brunetti, G

Diaz, G

Littera, M

Melis, S

Pani, M

Reali, R

Serra, S

Vacca, G

Carai, MAM

Gessa, GL

机构：

[1] Univ Cagliari, Bernard B Brodie Dept Neurosci, CNR, Ctr Neuropharmacol, I-09042 Monserrato, CA, Italy

[2] Neurosci Sca Rl, Cagliari, Italy

[3] Univ Cagliari, Dept Cytomorphol, I-09042 Monserrato, CA, Italy

来源：

BRAIN RESEARCH | 2001年 / 902卷 / 01期

关键词：

gamma-hydroxybutyric acid (GHB); sensitivity to the anesthetic effect; bidirectional selective breeding; GHB-sensitive (GHB-S) and GHB-resistant; (GHB-R); GABA(B) receptor;

D O I：

10.1016/S0006-8993(01)02389-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Two Wistar-derived rat lines, one sensitive (GHB-S) and the other resistant (GHB-R) to the anesthetic effect of gamma -hydroxybutyric acid (GHB), have been selectively bred. GHB-S and GHB-R rats were also sensitive and resistant, respectively, to the anesthetic effect of baclofen, the prototype GABA, receptor agonist, suggesting that they may be useful to elucidate not only the role of endogenous GHB but also that of GABA, receptors in sleep and anesthesia. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：127 / 130

页数：4

共 12 条

[1]

AGABIO R, 2001, IN PRESS GAMMAHYDROX

[2] Gamma-hydroxybutyric acid: an endogenous neuromodulator with abuse potential? [J].