NALOXONE ANTAGONIZES ETHANOL-HYDROXYBUTYRATE BUT NOT GAMMA-HYDROXYBUTYRATE-INDUCED SLEEP IN MICE

被引：24

作者：

DEVOTO, P

COLOMBO, G

CAPPAI, F

GESSA, GL

机构：

[1] 'Bernard B. Brodie' Department of Neuroscience, University of Cagliari, I-09124 Cagliari

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 252卷 / 03期

关键词：

DOPAC (DIHYDROXYPHENYLACETIC ACID); DOPAMINE; ETHANOL; GABA (GAMMA-HYDROXYBUTYRIC ACID); NALOXONE; SLEEP;

D O I：

10.1016/0014-2999(94)90179-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study examined the effect of naloxone on ethanol- and gamma-hydroxybutyric acid-induced narcosis in mice and the changes induced by these drugs on striatal dopamine metabolism. The results show that naloxone (1-10 mg/kg s.c.) markedly reduced ethanol-induced narcosis but failed to modify the duration of sleep induced by gamma-hydroxybutyrate. Naloxone (10 mg/kg) modified neither ethanol- nor gamma-hydroxybutyrate-induced changes in striatal dopamine and dihydroxyphenyracetic acid (DOPAC) content. The results suggest that gamma-hydroxybutyrate- and ethanol-induced narcosis are mediated by different mechanisms and that opioid receptors are not involved in the changes in dopamine metabolism induced by these compounds.

引用

页码：321 / 324

页数：4

共 15 条

[1] NALOXONE PRETREATMENT ALTERS THE LOCAL CEREBRAL METABOLIC EFFECT OF GAMMA-HYDROXYBUTYRATE IN RATS [J].