Compromised immunologic recovery in treatment-experienced patients with HIV infection receiving both tenofovir disoproxil fumarate and didanosine in the TORO studies

被引:16
作者
Negredo, E
Bonjoch, A
Paredes, R
Puig, J
Clotet, B
机构
[1] Hosp Badalona Germans Trias & Pujol, Badalona 08916, Spain
[2] Univ Autonoma Barcelona, Barcelona, Spain
关键词
D O I
10.1086/432879
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The effect of therapy with a combination of tenofovir and full-dose didanosine on increases in CD4(+) cell count was examined in 2 large trials of treatment-experienced patients with human immunodeficiency virus (HIV) infection (the T20 versus Optimized Regimen Only [TORO] 1 and 2 clinical trials). Individuals receiving both agents showed little additional increase in CD4(+) cell count after week 8 of therapy, whereas those receiving 1 or neither of the agents had continuous increases over a 48-week period.
引用
收藏
页码:901 / 905
页数:5
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