Coevolution of gene families in prokaryotes

被引：18

作者：

Cordero, Otto X. ^{[1
]}

Snel, Berend ^{[1
]}

Hogeweg, Paulien ^{[1
]}

机构：

[1] Univ Utrecht, NL-3584 CH Utrecht, Netherlands

来源：

GENOME RESEARCH | 2008年 / 18卷 / 03期

关键词：

D O I：

10.1101/gr.6815508

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We study gene family coevolution on a tree of life based on a large-scale ancestral gene content reconstruction, which includes gene duplication and deletion events. The insights obtained from this study are threefold: (1) Global properties, such as the distribution of coevolution partners and the formation of disconnected clusters of coevolving families, can be an inevitable consequence of evolution along a tree. (2) Concerted family expansion (gene duplication) and contraction (gene deletion) reflect functional constraints and therefore lead to better function prediction. (3) "Long-range" coevolutionary relationships, caused mostly by large family expansions or contractions, reveal high-level evolutionary organization of cellular processes in prokaryotes.

引用

收藏

页码：462 / 468

页数：7

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