Clinical Characteristics of Coronavirus Disease 2019 in China

被引：14627

作者：

Guan, W. ^{[1
]}

Ni, Z. ^{[7
]}

Hu, Yu ^{[8
]}

Liang, W. ^{[1
,2
]}

Ou, C. ^{[6
]}

He, J. ^{[1
,3
]}

Liu, L. ^{[14
,15
]}

Shan, H. ^{[17
]}

Lei, C. ^{[5
]}

Hui, D. S. C. ^{[18
]}

Du, B. ^{[21
]}

Li, L. ^{[23
]}

Zeng, G. ^{[22
]}

Yuen, K. -Y. ^{[16
,19
,20
]}

Chen, R. ^{[1
]}

Tang, C. ^{[1
]}

Wang, T. ^{[1
]}

Chen, P. ^{[6
]}

Xiang, J. ^{[7
]}

Li, S. ^{[1
]}

Wang, Jin-lin ^{[1
]}

Liang, Z. ^{[4
]}

Peng, Y. ^{[9
]}

Wei, L. ^{[10
]}

Liu, Y. ^{[24
]}

Hu, Ya-hua ^{[25
]}

Peng, P. ^{[11
]}

Wang, Jian-ming ^{[12
]}

Liu, J. ^{[26
]}

Chen, Z. ^{[27
]}

Li, G. ^{[28
]}

Zheng, Z. ^{[29
]}

Qiu, S. ^{[30
]}

Luo, J. ^{[31
]}

Ye, C. ^{[32
]}

Zhu, S. ^{[13
]}

Zhong, N. ^{[1
]}

机构：

[1] Guangzhou Med Univ, State Key Lab Resp Dis, Natl Clin Res Ctr Resp Dis, Guangzhou Inst Resp Hlth,Affiliated Hosp 1, 151 Yanjiang Rd, Guangzhou, Guangdong, Peoples R China

[2] Guangzhou Med Univ, Affiliated Hosp 1, Dept Thorac Oncol, Guangzhou, Peoples R China

[3] Guangzhou Med Univ, Affiliated Hosp 1, Dept Thorac Surg & Oncol, Guangzhou, Peoples R China

[4] Guangzhou Med Univ, Affiliated Hosp 1, Dept Emergency Med, Guangzhou, Peoples R China

[5] Guangzhou Med Univ, Guangzhou Peoples Hosp 8, Guangzhou, Peoples R China

[6] Southern Med Univ, Sch Publ Hlth, Guangdong Prov Key Lab Trop Dis Res, State Key Lab Organ Failure Res,Dept Biostat, Guangzhou, Peoples R China

[7] Wuhan Jinyintan Hosp, Wuhan, Peoples R China

[8] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Wuhan, Peoples R China

[9] Cent Hosp Wuhan, Wuhan, Peoples R China

[10] Wuhan Hosp Tradit Chinese & Western Med, Wuhan 1 Hosp, Wuhan, Peoples R China

[11] Wuhan Pulm Hosp, Wuhan, Peoples R China

[12] Wuhan Univ Sci & Technol, Tianyou Hosp, Wuhan, Peoples R China

[13] Peoples Hosp Huangpi Dist, Wuhan, Peoples R China

[14] Shenzhen Third Peoples Hosp, Shenzhen, Peoples R China

[15] Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Affiliated Hosp 2, Shenzhen, Peoples R China

[16] Univ Hong Kong, Shenzhen Hosp, Dept Clin Microbiol & Infect Control, Shenzhen, Peoples R China

[17] Sun Yat Sen Univ, Affiliated Hosp 5, Zhuhai, Peoples R China

[18] Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China

[19] Univ Hong Kong, Li Ka Shing Fac Med, Dept Microbiol, Pok Fu Lam, Hong Kong, Peoples R China

[20] Univ Hong Kong, Li Ka Shing Fac Med, Carol Yu Ctr Infect, Pok Fu Lam, Hong Kong, Peoples R China

[21] Peking Union Med Coll & Chinese Acad Med Sci, Peking Union Med Coll Hosp, Med ICU, Beijing, Peoples R China

[22] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China

[23] Zhejiang Univ, Coll Med, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis,Natl Cl, Hangzhou, Peoples R China

[24] Chengdu Publ Hlth Clin Med Ctr, Chengdu, Peoples R China

[25] Hubei Polytech Univ, Affiliated Hosp, Huangshi Cent Hosp, Edong Healthcare Grp, Huangshi, Hubei, Peoples R China

[26] First Hosp Changsha, Changsha, Peoples R China

[27] Third Peoples Hosp Hainan Prov, Sanya, Peoples R China

[28] Huanggang Cent Hosp, Huanggang, Peoples R China

[29] Wenling First Peoples Hosp, Wenling, Peoples R China

[30] Third Peoples Hosp Yichang, Yichang, Peoples R China

[31] Hubei Univ Med, Affiliated Taihe Hosp, Shiyan, Peoples R China

[32] Xiantao First Peoples Hosp, Xiantao, Peoples R China

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2020年 / 382卷 / 18期

关键词：

INFLUENZA; TRANSMISSION; PNEUMONIA; VIRUS; SARS;

D O I：

10.1056/NEJMoa2002032

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this study, researchers describe the clinical characteristics of coronavirus disease 2019 in a selected cohort of 1099 patients with laboratory-confirmed disease throughout mainland China during the first 2 months of the current outbreak. Background Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients. Methods We extracted data regarding 1099 patients with laboratory-confirmed Covid-19 from 552 hospitals in 30 provinces, autonomous regions, and municipalities in mainland China through January 29, 2020. The primary composite end point was admission to an intensive care unit (ICU), the use of mechanical ventilation, or death. Results The median age of the patients was 47 years; 41.9% of the patients were female. The primary composite end point occurred in 67 patients (6.1%), including 5.0% who were admitted to the ICU, 2.3% who underwent invasive mechanical ventilation, and 1.4% who died. Only 1.9% of the patients had a history of direct contact with wildlife. Among nonresidents of Wuhan, 72.3% had contact with residents of Wuhan, including 31.3% who had visited the city. The most common symptoms were fever (43.8% on admission and 88.7% during hospitalization) and cough (67.8%). Diarrhea was uncommon (3.8%). The median incubation period was 4 days (interquartile range, 2 to 7). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (CT) (56.4%). No radiographic or CT abnormality was found in 157 of 877 patients (17.9%) with nonsevere disease and in 5 of 173 patients (2.9%) with severe disease. Lymphocytopenia was present in 83.2% of the patients on admission. Conclusions During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness. Patients often presented without fever, and many did not have abnormal radiologic findings. (Funded by the National Health Commission of China and others.)

引用

页码：1708 / 1720

页数：13