Stem cell factor: Biology and relevance to clinical practice

被引：32

作者：

Smith, MA

Pallister, CJ

Smith, JG

机构：

[1] Royal United Hosp NHS Trust, Dept Haematol, Bath BA1 3NG, Avon, England

[2] Univ W England, Ctr Biomed Res, Bristol BS16 1QY, Avon, England

来源：

ACTA HAEMATOLOGICA | 2001年 / 105卷 / 03期

关键词：

stem cell factor; haemopoiesis; ex vivo; expansion; PBSC mobilisation; aplastic anaemia;

D O I：

10.1159/000046556

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The type III tyrosine kinase receptor c-KIT and its ligand stem cell factor (SCF; also known as KIT ligand, mast cell growth factor and steel factor) are closely involved in the regulation of a wide range of tissues at different stages of life. This review provides an outline of the discovery, structure and expression of SCF and c-KIT but concentrates on their respective roles in the regulation of human haemopoiesis and how this knowledge might be exploited in the clinical setting. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：143 / 150

页数：8

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