Genomic and functional characterization of polyunsaturated fatty acid biosynthesis in Caenorhabditis elegans

被引：38

作者：

Napier, JA ^{[1
]}

Michaelson, LV ^{[1
]}

机构：

[1] Univ Bristol, Dept Agr Sci, IARC Long Ashton Res Stn, Bristol BS41 9AF, Avon, England

来源：

LIPIDS | 2001年 / 36卷 / 08期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1007/s11745-001-0782-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The biosynthetic pathway for polyunsaturated fatty acids in the model animal Caenorhabditis elegans was examined in the context of the completed genome sequence. The genomic organization and location of seven desaturase genes and one elongase activity, all previously identified by functional characterization, were elucidated. A pathway for the biosynthesis of polyunsaturated fatty acids in C. elegans was proposed based on these genes. The role of gene duplication in enzyme evolution and proliferation is discussed.

引用

页码：761 / 766

页数：6

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