Biologically active 1-arylpiperazines.: Synthesis of new N-(4-aryl-1-piperazinyl)alkyl derivatives of quinazolidin-4(3H)-one, 2,3-dihydrophthalazine-1,4-dione and 1,2-dihydropyridazine-3,6-dione as potential serotonin receptor ligands

被引：17

作者：

Kowalski, P

Kowalska, T

Mokrosz, MJ

Bojarski, AJ

Charakchieva-Minol, S

机构：

[1] Cracow Univ Technol, Inst Organ Chem & Technol, PL-31155 Krakow, Poland

[2] Polish Acad Sci, Inst Pharmacol, Dept Med Chem, PL-31343 Krakow, Poland

来源：

MOLECULES | 2001年 / 6卷 / 09期

关键词：

arylpiperazines; lactams; serotonin receptor ligands;

D O I：

10.3390/60900784

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of a series of new n-propyl and n-butyl chain containing 1-aryl-piperazine derivatives of quinazolidin-4(3H)-one (7) 2-phenyl-2,3-dihydrophthalazine-1,4-dione (8) and 1-phenyl-1,2-dihydropyridazine-3,6-dione (9) as potential serotonin receptor ligands is described.

引用

页码：784 / 795

页数：12

共 31 条

[1] 3-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS OF 5-HT RECEPTOR-BINDING DATA FOR TETRAHYDROPYRIDINYLINDOLE DERIVATIVES - A COMPARISON OF THE HANSCH AND COMFA METHODS [J].